| Prescribing Information | Patient Information | Important Safety Information |
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| Thank you for registering |
| Dear ${user.firstName}, |
| Thank you for registering with VUMERITY® (diroximel fumarate)—approved for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. It is not known if VUMERITY is safe and effective in children. |
| You will receive updates about VUMERITY as they become available. In the meantime, you can learn more here or by calling Biogen Patient Services at 1-800-456-2255. |
| What is VUMERITY® (diroximel fumarate)? |
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VUMERITY is a prescription medicine used to treat people with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults |
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It is not known if VUMERITY is safe and effective in children |
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| Important Safety Information |
| Do not take VUMERITY if you: |
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have had an allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing) to diroximel fumarate, dimethyl fumarate, or any of the ingredients in VUMERITY |
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are taking dimethyl fumarate |
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| Before taking and while you take VUMERITY, tell your healthcare provider about all of your medical conditions, including if you: |
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have or have had low white blood cell counts or an infection |
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are pregnant or plan to become pregnant. It is not known if VUMERITY will harm your unborn baby |
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are pregnant or plan to become pregnant. It is not known if VUMERITY will harm your unborn baby |
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If you become pregnant while taking VUMERITY, talk to your healthcare provider about enrolling in the BlossoMS Pregnancy Registry. You can enroll in this registry by calling 1-833-569-2635 or visiting www.blossomspregnancyregistry.com. The purpose of this registry is to monitor the health of you and your baby |
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are breastfeeding or plan to breastfeed. It is not known if VUMERITY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using VUMERITY |
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| Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. |
| What should I avoid while taking VUMERITY? |
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Do not drink alcohol at the time you take a VUMERITY dose |
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| What are the possible side effects of VUMERITY? |
| VUMERITY may cause serious side effects including: |
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allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing). Stop taking VUMERITY and get emergency medical help right away if you get any of these symptoms |
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PML (progressive multifocal leukoencephalopathy) a rare brain infection that usually leads to death or severe disability over a period of weeks or months. Tell your healthcare provider right away if you get any of these symptoms of PML: |
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weakness on one side of the body that gets worse |
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clumsiness in your arms or legs |
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changes in thinking and memory |
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herpes zoster infections (shingles), including central nervous system infections |
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other serious infections |
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decreases in your white blood cell count. Your healthcare provider should do a blood test to check your white blood cell count before you start treatment with VUMERITY and while you are on therapy. You should have blood tests after 6 months of treatment and every 6 to 12 months after that |
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liver problems. Your healthcare provider should do blood tests to check your liver function before you start taking VUMERITY and during treatment if needed. Tell your healthcare provider right away if you get any of these symptoms of a liver problem during treatment |
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pain on the right side of your stomach |
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have dark or brown (tea color) urine |
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yellowing of your skin or the white part of your eyes |
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serious gastrointestinal problems, including bleeding, ulcers, blockage, and tears (perforation) of the stomach or intestines. Tell your healthcare provider right away if you have any of these symptoms during treatment: |
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stomach-area pain that does not go away |
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bright red or black stools (that look like tar) |
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coughing up blood or blood clots |
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vomiting blood or your vomit looks like “coffee grounds” |
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| The most common side effects of VUMERITY include: |
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flushing, redness, itching, or rash |
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nausea, vomiting, diarrhea, stomach pain, or indigestion |
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Flushing and stomach problems are the most common reactions, especially at the start of therapy, and may decrease over time. Taking VUMERITY with food (avoid high-fat, high-calorie meal or snack) may help reduce flushing. Call your healthcare provider if you have any of these symptoms and they bother you or do not go away. Ask your healthcare provider if taking aspirin before taking VUMERITY may reduce flushing |
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| These are not all the possible side effects of VUMERITY. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed.nlm.nih.gov |
| Please see full Prescribing Information, including Patient Information. |
| You received this email because you indicated that you want to receive information from Biogen, the sponsor of VUMERITY.com. Your name, address, and other personally identifiable information you provide will not be sold to any third party. If you do not wish to receive information from VUMERITY.com, please click here. |
